PXE国际关于弹性假黄瘤(PXE)的研究团队，对其的病因提出了现有的两种假设：积极的循环代谢产物或者组织特异性功能障碍。任务要求提供数据来求证这两种假设或其中之一。根据各地的发病机制进行实验，进一步了解PXE的病因。
这项任务保证至少会奖励一名挑战者，并且，除了任务奖金之外，PXE国际还将对中标者给予PXE的研究经费资助。
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PXE – Evaluating Hypotheses and Suggesting Experiments for a Rare Disease
TAGS: Computer Science/Information Technology, Chemistry, Global Health, Nature, Public Good, Life Sciences, Ideation
AWARD: $7,000 USD | DEADLINE: 11/30/12 | ACTIVE SOLVERS: 38 | POSTED: 10/31/12
The Seeker, PXE International, the primary group responsible for funding PXE research, presents two existing hypotheses (an active circulating metabolite(s) or a tissue-specific dysfunction) for the rare disease Pseudoxanthoma Elasticum (PXE). The Seeker requests that Solvers present evidence favoring one of the two hypotheses, then provide additional experiments to conduct to further knowledge around the disease mechanism.
This is an Ideation Challenge with a guaranteed award for at least one submitted solution. In addition to the Challenge award, PXE International will also assist finalists in efforts to obtain funding for PXE-related research.
Detailed Description & Requirements
INTRODUCTION TO PXE
Pseudoxanthoma Elasticum (PXE) is a recessive genetic disorder with signs and symptoms that mimic many aspects of the normal aging process, but at a much younger age (when people are roughly between 10 and 20 years old). Specifically, the disease is characterized by fragmentation and mineralization of elastic fibers in certain tissues. Some of the more common symptoms, in general order that they occur, are:
Wet-type macular degeneration
Skin wrinkling
Calcification of blood vessels
Cardiovascular disease
PXE is a rare disease with an estimated patient population of 12,000 people. Given the small number of people with the disease, it has not been the subject of research by for-profit pharmaceutical and biotech companies.
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